Dexrazoxane injection is available as 2 different products that are used to treat or prevent certain side effects that may be caused by chemotherapy medications. Dexrazoxane injection (Zinecard) is used to prevent or decrease heart damage caused by doxorubicin (Doxil) in women who are taking the medication to treat breast cancer that has spread to other parts of the body. Dexrazoxane injection (Zinecard) is not used to prevent heart damage in women who are just beginning treatment with doxorubicin; it is only given to women who have been treated with doxorubicin in the past and need continued treatment with doxorubicin. Dexrazoxane injection (Totect) is used to decrease damage to the skin and tissues that may be caused when an anthracycline chemotherapy medication such as daunorubicin (Daunoxome, Cerubidine), doxorubicin (Doxil), epirubicin (Ellence) or idarubicin (Idamycin) leaks out of a vein as it is being injected. Dexrazoxane injection is in classes of medications called cardioprotectants and chemoprotectants. It works by stopping the chemotherapy medications from damaging the heart and the tissues.
Dexrazoxane injection comes as a powder to be mixed with liquid and injected into a vein by a doctor or nurse in a hospital. When dexrazoxane injection is used to prevent heart damage caused by doxorubicin, it is given just before each dose of doxorubicin. When dexrazoxane injection is used to prevent tissue damage after an anthracycline medication has leaked out of a vein, it is given once a day for 3 days. The first dose is given as soon as possible within the first 6 hours after the leak occurs, and the second and third doses are given about 24 and 48 hours after the first dose.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before receiving dexrazoxane injection,
- tell your doctor and pharmacist if you are allergic to dexrazoxane injection or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention dimethylsulfoxide (DMSO).
- tell your doctor if you have or have ever had kidney or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving dexrazoxane injection, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving dexrazoxane injection.
- you should know that treatment with dexrazoxane injection decreases but does not eliminate the risk that doxorubicin will damage your heart. Your doctor will still need to monitor you carefully to see how doxorubicin has affected your heart.
Unless your doctor tells you otherwise, continue your normal diet.
Dexrazoxane injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- pain or swelling in the place where the medication was injected
- stomach pain
- loss of appetite
- excessive tiredness
- difficulty falling asleep or staying asleep
- swelling of the arms, hands, feet, ankles, or lower legs
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- sore throat, fever, chills, cough, and other signs of infection
- unusual bruising or bleeding
- pale skin
- shortness of breath
Some people who took a medication that is very similar to dexrazoxane injection developed new forms of cancer. There is not enough information to tell if receiving dexrazoxane injection increases the risk that you will develop a new type of cancer. Talk to your doctor about the risks of receiving this medication.
Dexrazoxane injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at Web Site] or by phone [1-800-332-1088].
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to dexrazoxane injection.
Ask your doctor or pharmacist any questions you have about dexrazoxane injection.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: February 11, 2012.