The information provided here is meant to give you a general idea about each of the medications listed below. Only the most general side effects are included. Ask your doctor if you need to take any special precautions. Use each of these medications as recommended by your doctor, or according to the instructions provided. If you have further questions about usage or side effects, contact your doctor.
Cold sores usually heal on their own within 7-20 days. Medications for the treatment of cold sores do not cure or rid the body of the virus. They may help to reduce the number of days an outbreak may last and may reduce discomfort.
- Acyclovir (Zovirax)
- Famciclovir (Famvir)
- Penciclovir (Denavir)
- Valacyclovir (Valtrex)
- Acetaminophen (Aceta, Apacet, Feverall, Panadol, Tylenol)
- Ibuprofen (Advil, Dolgesic, Genpril, Ibuprin, Motrin, Nuprin, Rufen)
Cold Sore Creams
- Benzocaine (Americaine Topical Anesthetic, Lagol)
Common names include:
(Aceta, Apacet, Feverall, Panadol, Tylenol)
(Advil, Dolgesic, Genpril, Ibuprin, Motrin, Nuprin, Rufen)
Pain relievers will help relieve the pain that accompanies a cold sore outbreak. They are taken on an as-needed basis. The dose depends on the amount of pain you are having. For severe pain and inflammation, ibuprofen is available in higher doses by prescription. Ibuprofen should be taken with food or a full glass of water.
Possible side effects include:
There are many cold sore creams and ointments available at drug stores that can help protect the lips and reduce the discomfort of a cold sore outbreak. These medications usually contain sunscreen and medicine to help releive pain.
Common brand names include:
Antibiotic ointments contain one or a combination of antibiotics that are sometimes effective in fighting bacterial skin infections. Cold sores are caused by a virus, not a bacteria, but these ointments may be used to help treat a secondary bacterial infection. They are applied, with clean hands, directly to the cold sore. They should not be used inside the mouth or too near the eyes. Use only as directed. Possible side effects include skin irritation or allergy.
Common names include:
(Americaine Topical Anesthetic, Lagol)
Anesthetic ointments work by numbing the area of the cold sore. This helps relieve the pain. Dry the area well before applying the ointment, and apply no more than four times per day. Side effects rarely occur.
If you are taking medications, follow these general guidelines:
- Take your medication as directed. Do not change the amount or the schedule.
- Know what side effects could occur. Discuss them with your doctor.
- Talk to your doctor before you stop taking the medication.
- Plan ahead for refills if you need them.
- Do not share your medication with anyone.
- Drugs can be dangerous when mixed. Talk to your doctor if you are taking more than one drug, including over-the-counter products and supplements.
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Kuehl B. Cold sores: how to prevent and treat them. Skin Care Guide website. Available at:
. Accessed March 20, 2013.
Last reviewed June 2013 by Brian Randall, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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