Canker sores are small ulcers in the mouth caused by an assortment of viruses. A susceptibility to canker sores tends to run in families. No successful conventional treatment is available.
A highly preliminary study suggests that a chemically altered form of the herb licorice known as
deglycyrrhizinated licorice (DGL) may be useful for speeding the resolution of canker sores.1 And, in a second, better designed trial employing a dissolving adhesive patch with glycyrrhiza root extract, researchers noted an improvement in ulcer size and pain compared to the use of a placebo patch.8
A product containing vitamins and minerals as well as the herbs paprika,
pumpkin seed has been used in Scandinavia for many years as a treatment for various mouth-related conditions. A small 6-month study reported that use of this product could reduce frequency of canker sores.2 However, two subsequent studies failed to find any meaningful benefit.3-4
One small double-blind study found benefits with an extract of the bark of the red mangrove tree,
A study performed in Iraq reported benefits through use of a mouthwash containing 5% lactic acid.7
Other herbs and supplements sometimes recommended for canker sores but lacking supporting evidence include
slippery elm, and
One study failed to find that alpha-linolenic acid from perilla oil reduced incidence of canker sores.6
In a small randomized trial with 50 people wiht recurrent canker sores, omega-3 fatty acids (1 gram, 3 times per day for 6 months) was associated with improvement in the number of ulcers, pain level of ulcers, and healing time of ulcers by up to 3 months when compared to placebo.9
Das SK, Das V, Gulati AK, et al. Deglycyrrhizinated liquorice in aphthous ulcers.
J Assoc Physicians India. 1989;37:647.
Pedersen A, Hougen HP, Klausen B et al. LongoVital in the prevention of recurrent aphthous ulceration.
J Oral Pathol Med. 1990;19:371-375.
Brateli J, Hakeberg M, Jontell M et al. The effect of LongoVital on recurrent aphthous stomatitis in a controlled clinical trial.
Oral Health Prev Dent. 2005;3:3-8.
Kolseth I, Herlofson B, Pedersen A et al. Norwegian LongoVital and recurrent aphthous ulceration: a randomized, double-blind, placebo-controlled study.
de Armas E, Sarracent Y, Marrero E et al. Efficacy of Rhizophora mangle aqueous bark extract (RMABE) in the treatment of aphthous ulcers: a pilot study.
Curr Med Res Opin.
Hamazaki K, Itomura M, Hamazaki T et al. Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial.
2006 Feb 9. [Epub ahead of print]
Sharquie KE, Al-Tammimy SM, Al-Mashhadani S, et al. Lactic acid 5 percent mouthwash is an effective mode of therapy in treatment of recurrent aphthous ulcerations.
Dermatol Online J.
Martin MD, Sherman J, van der Ven P, et al. A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers.
2008;56:206-210;quiz 211-212, 224.
El Khouli AM1, El-Gendy EA. Efficacy of omega-3 in treatment of recurrent aphthous stomatitis and improvement of quality of life: a randomized, double-blind, placebo-controlled study.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117(2):191-196.
Last reviewed August 2013 by EBSCO CAM Review Board
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