Lorcaserin is used to help adults who are obese or who are overweight and have weight-related medical problems to lose weight and keep from gaining back that weight. Lorcaserin must be used along with a reduced calorie diet and an exercise plan. Lorcaserin is in a class of medications called serotonin receptor agonists. It works by increasing feelings of fullness so that less food is eaten.
Lorcaserin comes as a tablet to take by mouth. It is usually taken with or without food twice a day. Take lorcaserin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lorcaserin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Lorcaserin may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.
If you do not lose a certain amount of weight during the first 12 weeks of your treatment, it is not likely that you will benefit from taking lorcaserin. Your doctor may tell you to stop taking lorcaserin if you do not lose enough weight during the first 12 weeks of your treatment.
Lorcaserin will help control your weight only if you continue to take it. Do not stop taking lorcaserin without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before taking lorcaserin,
- tell your doctor and pharmacist if you are allergic to lorcaserin, any other medications, or any of the ingredients in lorcaserin tablets. Ask your pharmacist or check the patient information for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications and vitamins you are taking or plan to take. Be sure to mention any of the following: bupropion (Aplenzin, Forfivo, Wellbutrin, Zyban); cabergoline; codeine (in some pain medications and cough medications); dextromethorphan (in cough and cold medications); flecainide (Tambocor); insulin and other medications for diabetes; linezolid (Zyvox); lithium (Lithobid); medications for erectile dysfunction, or mental illness; medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); other medications for weight loss; metoprolol (Toprol); mexiletine; monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); odansetron (Zofran); propafenone (Rythmol); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine, paroxetine (Paxil), and sertraline (Zoloft); selective serotonin/norepinephrine reuptake inhibitors (SNRIs) such as duloxetine (Cymbalta) and venlafaxine (Effexor); tamoxifen (Soltamox); timolol (Blocadren); tricyclic antidepressants (TCAs) such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); and tramadol (Conzip, Ultram, Ryzolt). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with lorcaserin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort, tryptophan, and herbs or supplements for weight loss.
- tell your doctor if you have or have ever had blood cell problems such as sickle cell anemia (a disease of the red blood cells), multiple myeloma (cancer of the plasma cells), or leukemia (cancer of the white blood cells); a condition that affects the shape of the penis such as angulation, cavernosal fibrosis, or Peyronie's disease;diabetes; heart failure, slow or irregular heartbeat, or other heart problems; or liver or kidney disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lorcaserin, call your doctor immediately. Lorcaserin may harm your unborn baby.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lorcaserin.
- you should know that lorcaserin may cause drowsiness and difficulty paying attention or remembering information. Do not drive a car or operate machinery until you know how this medication affects you.
Unless your doctor tells you otherwise, continue your normal diet.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Lorcaserin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dry mouth
- excessive tiredness
- pain in the back or muscles
- difficulty falling asleep or staying asleep
- difficult, painful, or frequent urination
- blurred vision or other vision changes
- dry eyes
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
- hallucinations (seeing things or hearing voices that are not there)
- difficulty with coordination
- muscle spasms, stiffness, or twitching
- fast, slow, or irregular heartbeat
- difficulty breathing
- swelling of the hands, arms, feet, or legs
- difficulty paying attention or remembering information
- thinking about harming or killing yourself or planning or trying to do so
- feeling high or unusually happy
- feeling as though you are outside of your body
- erection that lasts longer than 4 hours
- discharge from the breast
- breast enlargement in males
Lorcaserin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at Web Site] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include the following:
- stomach pain
- feeling high or unusually happy
- mood changes
- hallucinations (seeing things or hearing voices that do not exist)
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to lorcaserin.
Do not let anyone else take your medication. Lorcaserin is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: May 15, 2013.